CRISPR-Cas9 is a gene-editing technology with potential to expand the agricultural industry and improve human health. However, this technology may have unforeseeable consequences and adverse effects for society. Statistical procedures are often used to study public perceptions of controversial technologies. In this unit plan, students will design and administer surveys to investigate how their peers feel about various applications of gene-editing technology. In the process, students will apply random sampling methods and learn how to minimize response bias. Once their surveys are completed, students will analyze the results using contingency tables, confidence intervals, and hypothesis tests. The ultimate goal of this unit will be to help students to create clear policies for regulating the use of CRISPR-Cas9 and defend these policies with their statistical findings.

This unit focuses on the blending of vaccine focused content with basic biology content. The blending of content primarily concerns the human immune system. Allowing high school biology students to explore human vaccine technology through fundamental immune system knowledge and providing a tangible and relatable way to engage with these two complex topics to aid student understanding of how a vaccine works on the individual level. Prior to addressing the science behind how a vaccine leverages the immune system some vaccine focused content will provide a brief history of vaccines and explanation of vaccine types. Herd immunity will also be discussed within the unit. Herd immunity refers to the percentage of immune population threshold that is necessary to avoid an epidemic. Herd immunity is about understanding how vaccines work on a population level. It is relevant that students understand that vaccines are not just an individual health issue and are perhaps more importantly a community health issue. These topic areas will also allow the unit to explore the pressing and relevant vaccine related issue of barriers to vaccine adoption and public adoption of vaccine protocols. Finally, the likely future of vaccine technology, DNA vaccines, will be discussed. DNA vaccines offer much promise in eliminating some inherent vaccination issues such as transport, storage, ease of production, and safety.

The main content covered in this unit includes the Structure and Function of the biological molecules, the energy flow and the nutrients, Nutritional Facts Labels, and the My Plate concept. Proteins, nucleic acids, polysaccharides in carbohydrates are considered macromolecules, and the lipid molecules are considered as biomolecules. For clarity purposes, proteins, nucleic acids, carbohydrates, and fats will be referred to as “biological molecules” throughout the unit. The history of studying these biological molecules dates back to the early 19th century. British physician-chemist, William Prout (1785-1850) was the first to classify “foodstuffs or ingredients of life into saccharinous (carbohydrates), oleaginous (fats), and albuminous (proteins)” and urged that “a satisfactory diet should include carbohydrates, fats, protein, and water”3. Carl Schmidt coined the term “carbohydrates” in 1844.