The January 2012 issue of PLOS Neglected Tropical Diseases presented an Editorial, …
The January 2012 issue of PLOS Neglected Tropical Diseases presented an Editorial, a Viewpoint, and two accompanying Expert Commentaries that focussed on the application of genetically modified (GM) insects for control of animal and plant diseases. These articles describe the technological advances these tools represent, the regulatory framework, and the societal dialogue that is necessary for their wide-scale application for disease control. Here, we have assembled a collection of articles published in the PLOS journals that describe the technical and applied aspects of GM insects. We also included articles that are not strictly GM, but aim to modify the disease transmission traits of insects through the use of symbiotic microbes.
Tsetse flies are important vectors of human and animal diseases that adversely …
Tsetse flies are important vectors of human and animal diseases that adversely impact life in sub-Sahara Africa. A community of tsetse researchers (International Glossina Genome Initiative) have been working to obtain the full genome sequence of the tsetse species Glossina morsitans morsitans. The group have also mined the genome data to advance knowledge on functional aspects of tsetse and African trypanosome biology. This collection describes findings on tsetse's salivary gland biology, olfactory chemistry, lactation process, acquaporin proteins that play a role in lactation, oxidative stress responses during pregnancy, gut peritrophic matrix analysis and horizontal transfer events discovered in tsetse's genome from the symbiont Wolbachia. Further manuscripts reflect on the historical aspects of sleeping sickness epidemics that have plagued sub-Sahara in the 20th century.
Zika is an arbovirus infection transmitted by several different species of Aedes …
Zika is an arbovirus infection transmitted by several different species of Aedes mosquitoes, including Aedes aegypti in the New World. Towards the end of 2015, the Pan American Health Organization announced a possible link between zika and congenital birth defects, in particularly a neurodevastating birth defect known as microcephaly. The causal link between zika and microcephaly has still not been confirmed, but preliminary evidence for an association has been found. The impact of zika virus should be treated with the utmost seriousness as the effects could be devastating. In response a call for research on the outbreak and a new PLOS Collection, which will collate research and other resources related to the outbreak, have been launched.
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