The Manitoba Foundations Guide (Brandon Edition) is the first Manitoba adaptation of an open professional learning series developed for staff across post-secondary institutions. Guides developed in the series include: Foundations1; Leaders and Administrators2; Curriculum Developers3; Teachers and Instructors4; Front-Line Staff, Student Services, and Advisors5; and Researchers6. This guide is an adaptation of the Foundations Guide published by BCcampus and the Ministry of Advanced Education in collaboration with a steering committee of Indigenous education leaders from post-secondary institutions in British Columbia. This guide is intended to support the systemic change occurring across post-secondary institutions and beyond through Indigenization, decolonization, and reconciliation. A guiding principle from the Truth and Reconciliation Commission of Canada process states why this change is happening.